KMID : 0389520170240020086
|
|
Sleep Medicine.Psychophysiology 2017 Volume.24 No. 2 p.86 ~ p.96
|
|
The Effects of Sleep Apnea and Variables on Cognitive Function and the Mediating Effect of Depression
|
|
Park Kyung-Won
Kim Hyeong-Wook Choi Mal-Rye Kim Byong-Jo Kim Tae-Hyung Song Ok-Sun Eun Hun-Jeong
|
|
Abstract
|
|
|
Objectives: This study aimed to analyze causality among sleep apnea, depression and cognitive function in patients with obstructive sleep apnea.
Methods: We reviewed the medical records of 105 patients with sleep apnea and snoring who underwent overnight polysomnography (PSG). We analyzed various biological data, sleep variables (sleep duration and percentage) and respiratory variables [arousal index (AI), periodic leg movement index (PLM index), snoring Index (SI), mean SpO2, minimum SpO2, apnea-hypopnea index (AHI), and respiratory disturbance index (RDI)]. We also analyzed various data by sleep, cognition, and mood related scales: Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale (ESS), snoring index by scale (SIS), Montreal Cognitive Assessment-Korean (Moca-K), Mini-mental State Examination-Korean (MMSE-K), clinical dementia rating (CDR), and Beck Depression Inventory (BDI). We analyzed causation among sleep, and respiratory, mood, and cognition related scales in obstructive sleep apnea patients. We analyzed the mediating effects of depression on sleep apnea patient cognition.
Results: As Duration N1 increased and Total sleep time (TST) decreased, MOCA-K showed negative causality (p £¼ 0.01). As BDI and supine RDI increased, causality was negatively related to MOCA-K (p £¼ 0.01). As PSQI (p £¼ 0.001) and SIS (p £¼ 0.01) increased and as MMSE-K (p £¼ 0.01) decreased, causality was positively related to BDI. BDI was found to mediate the effect of age on MOCA-K in patients with obstructive sleep apnea.
Conclusion: Duration N1, total sleep time, BDI, and supine RDI were associated with cognitive function in obstructive sleep apnea patients. Depression measured by BDI partially mediated cognitive decline in obstructive sleep apnea patients.
|
|
KEYWORD
|
|
Cognitive function, Depression, Polysomnography, Sleep apnea, Sleep variables
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|